MRL-24 | 2764

Cell-permeable. MRL-24 displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. Highly effective (30 nM) at blocking Cdk5-mediated phosphorylation of PPARγ.

MRL-24 displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. Highly effective (30 nM) at blocking Cdk5-mediated phosphorylation of PPARγ.

2764 | MRL-24 DataSheet

Alternate Name/Synonyms: (S)-2-(3-((1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl)methyl)phenoxy)propanoic acid

Appearance: White solid

Formulation: N/A

CAS Number: N/A

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₂₄F₃NO₆

Molecular Weight: 527.49

Cell-Permeable?: Y

Purity: ≥98% by TLC

Solubilities: DMSO (~ 30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A PPARγ agonist

MDL Number: N/A

PubChem CID: N/A

SMILES: CC1=C(CC2=CC(O[C@H](C(O)=O)C)=CC=C2)C3=CC(OC(F)(F)F)=CC=C3N1C(C4=CC=C(OC)C=C4)=O

InChi: InChI=1S/C28H24F3NO6/c1-16-23(14-18-5-4-6-21(13-18)37-17(2)27(34)35)24-15-22(38-28(29,30)31)11-12-25(24)32(16)26(33)19-7-9-20(36-3)10-8-19/h4-13,15,17H,14H2,1-3H3,(H,34,35)

InChi Key: OFCWBJAYEIROGZ-UHFFFAOYSA-N