Description
Cell-permeable. MRL-24 displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. Highly effective (30 nM) at blocking Cdk5-mediated phosphorylation of PPARγ.
MRL-24 displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. Highly effective (30 nM) at blocking Cdk5-mediated phosphorylation of PPARγ.
Alternate Name/Synonyms: (S)-2-(3-((1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl)methyl)phenoxy)propanoic acid
Appearance: White solid
Formulation: N/A
CAS Number: N/A
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₈H₂₄F₃NO₆
Molecular Weight: 527.49
Cell-Permeable?: Y
Purity: ≥98% by TLC
Solubilities: DMSO (~ 30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A PPARγ agonist
MDL Number: N/A
PubChem CID: N/A
SMILES: CC1=C(CC2=CC(O[C@H](C(O)=O)C)=CC=C2)C3=CC(OC(F)(F)F)=CC=C3N1C(C4=CC=C(OC)C=C4)=O
InChi: InChI=1S/C28H24F3NO6/c1-16-23(14-18-5-4-6-21(13-18)37-17(2)27(34)35)24-15-22(38-28(29,30)31)11-12-25(24)32(16)26(33)19-7-9-20(36-3)10-8-19/h4-13,15,17H,14H2,1-3H3,(H,34,35)
InChi Key: OFCWBJAYEIROGZ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |