N-Oxalylglycine | B1084

N-Oxalylglycine, the amide analog of α-ketoglutarate, is a cell-permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E (IC₅₀s = 250, 500, and 24 μM, respectively). It can also inhibit the prolyl hydroxylase domain-containing proteins PHD1 and PHD2 with IC₅₀ values of 2.1 and 5.6 μM, respectively.

N-Oxalylglycine, the amide analog of α-ketoglutarate, is a cell-permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E (IC₅₀s = 250, 500, and 24 μM, respectively). It can also inhibit the prolyl hydroxylase domain-containing proteins PHD1 and PHD2 with IC₅₀ values of 2.1 and 5.6 μM, respectively.

B1084 | N-Oxalylglycine DataSheet

Alternate Name/Synonyms: 2-(Carboxymethylamino)-2-oxoacetic acid

Appearance: White Solid

Formulation: N/A

CAS Number: 5262-39-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄H₅NO₅

Molecular Weight: 147.1

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A cell-permeable inhibitor of α-ketoglutarate-dependent enzymes

MDL Number: MFCD00913253

PubChem CID: 3080614

SMILES: C(C(=O)O)NC(=O)C(=O)O

InChi: InChI=1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)

InChi Key: BIMZLRFONYSTPT-UHFFFAOYSA-N