Description
N-Oxalylglycine, the amide analog of α-ketoglutarate, is a cell-permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E (IC₅₀s = 250, 500, and 24 μM, respectively). It can also inhibit the prolyl hydroxylase domain-containing proteins PHD1 and PHD2 with IC₅₀ values of 2.1 and 5.6 μM, respectively.
N-Oxalylglycine, the amide analog of α-ketoglutarate, is a cell-permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E (IC₅₀s = 250, 500, and 24 μM, respectively). It can also inhibit the prolyl hydroxylase domain-containing proteins PHD1 and PHD2 with IC₅₀ values of 2.1 and 5.6 μM, respectively.
B1084 | N-Oxalylglycine DataSheet
Alternate Name/Synonyms: 2-(Carboxymethylamino)-2-oxoacetic acid
Appearance: White Solid
Formulation: N/A
CAS Number: 5262-39-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₄H₅NO₅
Molecular Weight: 147.1
Cell-Permeable?: Yes
Purity: ≥95% by HPLC
Solubilities: DMSO (~10 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A cell-permeable inhibitor of α-ketoglutarate-dependent enzymes
MDL Number: MFCD00913253
PubChem CID: 3080614
SMILES: C(C(=O)O)NC(=O)C(=O)O
InChi: InChI=1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)
InChi Key: BIMZLRFONYSTPT-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |