Description
The major flavanone found in grapefruit. Acts as an antioxidant, free radical scavenger and carbohydrate metabolism promoter. Shows cytotoxicity in various human cell lines and promotes apoptosis in rat C6 glioma model. Naringenin seems to protect LDL-receptor deficient mice from the obesity effects of a high-fat diet. Also lowers the plasma and hepatic cholesterol concentrations by suppressing HMG-CoA reductase and ACAT in rats fed with a high-cholesterol diet.
Naringenin is the major flavanone found in grapefruit. Acts as an antioxidant, free radical scavenger and carbohydrate metabolism promoter. Shows cytotoxicity in various human cell lines and promotes apoptosis in rat C6 glioma model. Naringenin seems to protect LDL-receptor deficient mice from the obesity effects of a high-fat diet.
Alternate Name/Synonyms: 5,7,4'-Trihydroxyflavanone; 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; NGEN
Appearance: Brown solid
Formulation: N/A
CAS Number: 480-41-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₁₂O₅
Molecular Weight: 272.26
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO or EtOH (50 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An antioxidant and an ACAT inhibitor
MDL Number: MFCD00006844
PubChem CID: 932
SMILES: C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O
InChi: InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2
InChi Key: FTVWIRXFELQLPI-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |