Description
NE-100 is a potent antagonist of sigma-1 (σ1) receptor. It inhibits binding of (+)-pentazocine binding to sigma-1 binding sites with an IC₅₀ value of 1.54 nM. NE-100 attenuates phencyclidin induced head-weaving behavior or ataxia in experimental animals. It suppresses ER stress-induced cell death by the upregulation of 78-kDa glucose-regulated protein (GRP78). Modulators of sigma receptors are suggested to show activity against SARS-CoV-2, based on interaction of SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors.
NE-100 is a potent antagonist of sigma-1 (σ1) receptor. It inhibits binding of (+)-pentazocine binding to sigma-1 binding sites with an IC₅₀ value of 1.54 nM. NE-100 attenuates phencyclidin induced head-weaving behavior or ataxia in experimental animals. It suppresses ER stress-induced cell death by the upregulation of 78-kDa glucose-regulated protein (GRP78). Modulators of sigma receptors are suggested to show activity against SARS-CoV-2, based on interaction of SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors.
B3047 | NE-100 hydrochloride DataSheet
Alternate Name/Synonyms: N-[2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl]-N-propylpropan-1-amine;hydrochloride; 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride
Appearance: White solid
Formulation:
CAS Number: 149409-57-4
Structure Available?: TRUE
Peptide sequence:
Salt Form: TRUE
Molecular Formula: C₂₃H₃₄ClNO₂
Molecular Weight: 391.97
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: ~39 mg/ml in DMSO; ~10 mg/ml in water
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent antagonist of sigma-1 receptor
MDL Number: MFCD00922105
PubChem CID: 9952420
SMILES: CCCN(CCC)CCC1=CC(=C(C=C1)OC)OCCC2=CC=CC=C2.Cl
InChi: InChI=1S/C23H33NO2.ClH/c1-4-15-24(16-5-2)17-13-21-11-12-22(25-3)23(19-21)26-18-14-20-9-7-6-8-10-20;/h6-12,19H,4-5,13-18H2,1-3H3;1H
InChi Key: ZHGMDXSHODHWHV-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |