NE-100 hydrochloride | B3047

NE-100 is a potent antagonist of sigma-1 (σ1) receptor. It inhibits binding of (+)-pentazocine binding to sigma-1 binding sites with an IC₅₀ value of 1.54 nM. NE-100 attenuates phencyclidin induced head-weaving behavior or ataxia in experimental animals. It suppresses ER stress-induced cell death by the upregulation of 78-kDa glucose-regulated protein (GRP78). Modulators of sigma receptors are suggested to show activity against SARS-CoV-2, based on interaction of SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors.

NE-100 is a potent antagonist of sigma-1 (σ1) receptor. It inhibits binding of (+)-pentazocine binding to sigma-1 binding sites with an IC₅₀ value of 1.54 nM. NE-100 attenuates phencyclidin induced head-weaving behavior or ataxia in experimental animals. It suppresses ER stress-induced cell death by the upregulation of 78-kDa glucose-regulated protein (GRP78). Modulators of sigma receptors are suggested to show activity against SARS-CoV-2, based on interaction of SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors.

B3047 | NE-100 hydrochloride DataSheet

Alternate Name/Synonyms: N-[2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl]-N-propylpropan-1-amine;hydrochloride; 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride

Appearance: White solid

Formulation:

CAS Number: 149409-57-4

Structure Available?: TRUE

Peptide sequence:

Salt Form: TRUE

Molecular Formula: C₂₃H₃₄ClNO₂

Molecular Weight: 391.97

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~39 mg/ml in DMSO; ~10 mg/ml in water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent antagonist of sigma-1 receptor

MDL Number: MFCD00922105

PubChem CID: 9952420

SMILES: CCCN(CCC)CCC1=CC(=C(C=C1)OC)OCCC2=CC=CC=C2.Cl

InChi: InChI=1S/C23H33NO2.ClH/c1-4-15-24(16-5-2)17-13-21-11-12-22(25-3)23(19-21)26-18-14-20-9-7-6-8-10-20;/h6-12,19H,4-5,13-18H2,1-3H3;1H

InChi Key: ZHGMDXSHODHWHV-UHFFFAOYSA-N