NEK11L Antibody (C-term) [APR17558G]

NEK11L Antibody (C-term) [APR17558G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This NEK11L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 480-510 amino acids from the C-terminal region of human NEK11L.

Cellular Localisation: Nucleus. Nucleus, nucleolus. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase (PubMed:12154088) . Accumulates in the nucleolus in G1/S-arrested cells (PubMed:15161910) .

Molecular Weight: 74192

Clone: Polyclonal

Gene Name: NEK11 (HGNC:18593)

Gene ID: 79858

Function: Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.

Summary: Tissue Location: Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Serine/threonine-protein kinase Nek11, Never in mitosis A-related kinase 11, NimA-related protein kinase 11, NEK11 (HGNC:18593)