NKL 22 (MDK-4154) | B1133

NKL 22 (also known as MDK-4154) is a cell-permeable compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. It reverses the silencing of FXN transcription in FRDA (Friedreich’s ataxia) cells due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K12, and H4K5 without much acetylation on H3K9, H4K8 and H4K16.

NKL 22 (also known as MDK-4154) is a cell-permeable compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. It reverses the silencing of FXN transcription in FRDA (Friedreich’s ataxia) cells due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K12, and H4K5 without much acetylation on H3K9, H4K8 and H4K16.

B1133 | NKL 22 (MDK-4154) DataSheet

Alternate Name/Synonyms: N1-(2-aminophenyl)-N7-phenylheptanediamide

Appearance: Beige to pale white solid

Formulation: N/A

CAS Number: 537034-15-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₃N₃O₂

Molecular Weight: 325.4

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A histone deacetylase (HDAC) inhibitor

MDL Number: N/A

PubChem CID: 9543539

SMILES: C1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N

InChi: 1S/C19H23N3O2/c20-16-11-7-8-12-17(16)22-19(24)14-6-2-5-13-18(23)21-15-9-3-1-4-10-15/h1,3-4,7-12H,2,5-6,13-14,20H2,(H,21,23)(H,22,24)

InChi Key: ZAIULUYKQLVQFH-UHFFFAOYSA-N