Description
NKL 22 (also known as MDK-4154) is a cell-permeable compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. It reverses the silencing of FXN transcription in FRDA (Friedreich’s ataxia) cells due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K12, and H4K5 without much acetylation on H3K9, H4K8 and H4K16.
NKL 22 (also known as MDK-4154) is a cell-permeable compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. It reverses the silencing of FXN transcription in FRDA (Friedreich’s ataxia) cells due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K12, and H4K5 without much acetylation on H3K9, H4K8 and H4K16.
B1133 | NKL 22 (MDK-4154) DataSheet
Alternate Name/Synonyms: N1-(2-aminophenyl)-N7-phenylheptanediamide
Appearance: Beige to pale white solid
Formulation: N/A
CAS Number: 537034-15-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₂₃N₃O₂
Molecular Weight: 325.4
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (100 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A histone deacetylase (HDAC) inhibitor
MDL Number: N/A
PubChem CID: 9543539
SMILES: C1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N
InChi: 1S/C19H23N3O2/c20-16-11-7-8-12-17(16)22-19(24)14-6-2-5-13-18(23)21-15-9-3-1-4-10-15/h1,3-4,7-12H,2,5-6,13-14,20H2,(H,21,23)(H,22,24)
InChi Key: ZAIULUYKQLVQFH-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |