NQTrp | B2981

NQTrp is an inhibitor of amyloid β (Aβ) oligomerization and fibrillization, with an IC₅₀ of 50 nM for formation of fibrils from Aβ1-42. It reduces the cytotoxic effect of Aβ oligomers in rat PC12 neuronal cell line. It also increases the life span and completely abolishes defective locomotion in a transgenic Alzheimer's disease Drosophila model.

NQTrp is an inhibitor of amyloid β (Aβ) oligomerization and fibrillization, with an IC₅₀ of 50 nM for formation of fibrils from Aβ1-42. It reduces the cytotoxic effect of Aβ oligomers in rat PC12 neuronal cell line. It also increases the life span and completely abolishes defective locomotion in a transgenic Alzheimer's disease Drosophila model.

B2981 | NQTrp DataSheet

Alternate Name/Synonyms: N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan; (2S)-2-[(1,4-dioxonaphthalen-2-yl)amino]-3-(1H-indol-3-yl)propanoic acid; 1,4-naphthoquinon-2-yl-l-tryptophan

Appearance: Solid

Formulation:

CAS Number: 185351-19-3

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₁H₁₆N₂O₄

Molecular Weight: 360.36

Cell-Permeable?: True

Purity: 98%

Solubilities: ~20 mg/ml in DMSO and DMF in 0, ~1 mg/ml in in Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent inhibitor of amyloid β aggregation

MDL Number:

PubChem CID: 56605052

SMILES: C1=CC=C2C(=C1)C(=O)C=C(C2=O)NC(CC3=CNC4=CC=CC=C43)C(=O)O

InChi: InChI=1S/C21H16N2O4/c24-19-10-17(20(25)15-7-2-1-6-14(15)19)23-18(21(26)27)9-12-11-22-16-8-4-3-5-13(12)16/h1-8,10-11,18,22-23H,9H2,(H,26,27)/t18-/m0/s1

InChi Key: DZZUYZXINNHEGM-SFHVURJKSA-N