Description
NS-1619 is a calcium-dependent activator of large-conductance Ca²⁺-activated K⁺ (BKCa) channels in vascular smooth muscle. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC₅₀ = 3.6 μM).
NS-1619 is a calcium-dependent activator of large-conductance Ca²⁺-activated K⁺ (BKCa) channels in vascular smooth muscle. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC₅₀ = 3.6 μM).
Alternate Name/Synonyms: 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
Appearance: White solid
Formulation: N/A
CAS Number: 153587-01-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₈F₆N₂O₂
Molecular Weight: 362.23
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A calcium-dependent activator of large-conductance Ca²⁺-activated K⁺ (BKCa) channels
MDL Number: MFCD00928190
PubChem CID: 4552
SMILES: C1=CC2=C(C=C1C(F)(F)F)NC(=O)N2C3=C(C=CC(=C3)C(F)(F)F)O
InChi: InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
InChi Key: YLFMCMWKHSDUCT-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |