NS-1619 | B1303

NS-1619 is a calcium-dependent activator of large-conductance Ca²⁺-activated K⁺ (BKCa) channels in vascular smooth muscle. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC₅₀ = 3.6 μM).

NS-1619 is a calcium-dependent activator of large-conductance Ca²⁺-activated K⁺ (BKCa) channels in vascular smooth muscle. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC₅₀ = 3.6 μM).

B1303 | NS-1619 DataSheet

Alternate Name/Synonyms: 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one

Appearance: White solid

Formulation: N/A

CAS Number: 153587-01-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₈F₆N₂O₂

Molecular Weight: 362.23

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A calcium-dependent activator of large-conductance Ca²⁺-activated K⁺ (BKCa) channels

MDL Number: MFCD00928190

PubChem CID: 4552

SMILES: C1=CC2=C(C=C1C(F)(F)F)NC(=O)N2C3=C(C=CC(=C3)C(F)(F)F)O

InChi: InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)

InChi Key: YLFMCMWKHSDUCT-UHFFFAOYSA-N