Description
NSC-319726 is a reactivator of mutant p53. It restores WT structure and function to the p53(R175) mutant. NSC-319726 kills p53(R172H) knockin mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner.
NSC-319726 is a reactivator of mutant p53. It restores WT structure and function to the p53(R175) mutant. NSC-319726 kills p53(R172H) knockin mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner.
Alternate Name/Synonyms: 1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide
Appearance: White solid
Formulation: N/A
CAS Number: 71555-25-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₁H₁₄N₄S
Molecular Weight: 234.32
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO (>20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A reactivator of mutant p53
MDL Number: N/A
PubChem CID: 5921672
SMILES: CC(=NNC(=S)N1CCC1)C2=CC=CC=N2
InChi: InChI=1S/C11H14N4S/c1-9(10-5-2-3-6-12-10)13-14-11(16)15-7-4-8-15/h2-3,5-6H,4,7-8H2,1H3,(H,14,16)/b13-9-
InChi Key: XDHBUMNIQRLHGO-LCYFTJDESA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |