NSC-319726 | 9439

NSC-319726 is a reactivator of mutant p53. It restores WT structure and function to the p53(R175) mutant. NSC-319726 kills p53(R172H) knockin mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner.

NSC-319726 is a reactivator of mutant p53. It restores WT structure and function to the p53(R175) mutant. NSC-319726 kills p53(R172H) knockin mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner.

9439 | NSC-319726 DataSheet

Alternate Name/Synonyms: 1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide

Appearance: White solid

Formulation: N/A

CAS Number: 71555-25-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₁₄N₄S

Molecular Weight: 234.32

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A reactivator of mutant p53

MDL Number: N/A

PubChem CID: 5921672

SMILES: CC(=NNC(=S)N1CCC1)C2=CC=CC=N2

InChi: InChI=1S/C11H14N4S/c1-9(10-5-2-3-6-12-10)13-14-11(16)15-7-4-8-15/h2-3,5-6H,4,7-8H2,1H3,(H,14,16)/b13-9-

InChi Key: XDHBUMNIQRLHGO-LCYFTJDESA-N