NU6102 | 2313

A potent inhibitor of CDK1 and CDK2 with Ki values of 9 and 6 nM and IC₅₀ values of 9.5 and 5.4 nM, respectively. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC₅₀ = 1.6 μM), DYRK1A (IC₅₀ = 0.9 μM), PDK1 (IC₅₀ = 0.8 μM) and ROCK-II (IC₅₀ = 0.6 μM). Inhibits cell growth.

NU6102 is a potent inhibitor of CDK1 and CDK2 with Ki values of 9 and 6 nM and IC₅₀ values of 9.5 and 5.4 nM, respectively.

2313 | NU6102 DataSheet

Alternate Name/Synonyms: O6-Cyclohexylmethyl-2-(4-sulfamoylanilino)purine; 4-​[[6-​(cyclohexylmethoxy)-​9H-​purin-​2-​yl]amino]-​benzenesulfonamide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 444722-95-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₂N₆O₃S

Molecular Weight: 402.47

Cell-Permeable?: Yes

Purity: ≥98% by NMR

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent CDK1 and CDK2 inhibitor

MDL Number: N/A

PubChem CID: 4566

SMILES: C1CCC(CC1)COC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)S(=O)(=O)N

InChi: InChI=1S/C18H22N6O3S/c19-28(25,26)14-8-6-13(7-9-14)22-18-23-16-15(20-11-21-16)17(24-18)27-10-12-4-2-1-3-5-12/h6-9,11-12H,1-5,10H2,(H2,19,25,26)(H2,20,21,22,23,24)

InChi Key: OWXORKPNCHJYOF-UHFFFAOYSA-N