Description
A potent inhibitor of CDK1 and CDK2 with Ki values of 9 and 6 nM and IC₅₀ values of 9.5 and 5.4 nM, respectively. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC₅₀ = 1.6 μM), DYRK1A (IC₅₀ = 0.9 μM), PDK1 (IC₅₀ = 0.8 μM) and ROCK-II (IC₅₀ = 0.6 μM). Inhibits cell growth.
NU6102 is a potent inhibitor of CDK1 and CDK2 with Ki values of 9 and 6 nM and IC₅₀ values of 9.5 and 5.4 nM, respectively.
Alternate Name/Synonyms: O6-Cyclohexylmethyl-2-(4-sulfamoylanilino)purine; 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-benzenesulfonamide
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 444722-95-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₂₂N₆O₃S
Molecular Weight: 402.47
Cell-Permeable?: Yes
Purity: ≥98% by NMR
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent CDK1 and CDK2 inhibitor
MDL Number: N/A
PubChem CID: 4566
SMILES: C1CCC(CC1)COC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)S(=O)(=O)N
InChi: InChI=1S/C18H22N6O3S/c19-28(25,26)14-8-6-13(7-9-14)22-18-23-16-15(20-11-21-16)17(24-18)27-10-12-4-2-1-3-5-12/h6-9,11-12H,1-5,10H2,(H2,19,25,26)(H2,20,21,22,23,24)
InChi Key: OWXORKPNCHJYOF-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |