Nucleozin | B2064

Nucleozin is an antiviral agent that triggers the aggregation of nucleoprotein (NP) and inhibits its nuclear accumulation. Nucleozin impedes influenza A virus replication in vitrowith a nanomolar median effective concentration (EC50) and protects mice challenged with lethal doses of avian influenza A H5N1. Nucleozin is effective in fighting H1N1, H3N2, and H5N1 flu virus strains by inducing the formation of NP aggregates and antagonizing its nuclear accumulation, leading to cessation of viral replication.

Nucleozin is an antiviral agent that triggers the aggregation of nucleoprotein (NP) and inhibits its nuclear accumulation. Nucleozin impedes influenza A virus replication in vitrowith a nanomolar median effective concentration (EC50) and protects mice challenged with lethal doses of avian influenza A H5N1. Nucleozin is effective in fighting H1N1, H3N2, and H5N1 flu virus strains by inducing the formation of NP aggregates and antagonizing its nuclear accumulation, leading to cessation of viral replication.

B2064 | Nucleozin DataSheet

Alternate Name/Synonyms: 1-(2-Chloro-4-nitrophenyl)-4-[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]-piperazine

Appearance: Yellow solid

Formulation: N/A

CAS Number: 341001-38-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₉ClN₄O₄

Molecular Weight: 426.86

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An antiviral agent

MDL Number: MFCD01426660

PubChem CID: 2863945

SMILES: CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)N3CCN(CC3)C4=C(C=C(C=C4)[N+](=O)[O-])Cl

InChi: InChI=1S/C21H19ClN4O4/c1-14-19(20(23-30-14)15-5-3-2-4-6-15)21(27)25-11-9-24(10-12-25)18-8-7-16(26(28)29)13-17(18)22/h2-8,13H,9-12H2,1H3

InChi Key: OWXBJAPOSQSWAO-UHFFFAOYSA-N