Description
NVP-BEP800 is a potent oral inhibitor of Hsp90β (IC₅₀ = 58 nM). Displays strong anti-proliferative activity against various tumor cell lines and primary tumors in vitro and in vivo at well-tolerated doses.
NVP-BEP800 is a potent oral inhibitor of Hsp90β (IC₅₀ = 58 nM). Displays strong anti-proliferative activity against various tumor cell lines and primary tumors in vitro and in vivo at well-tolerated doses.
Alternate Name/Synonyms: 2-amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethyl-thieno[2,3-d]pyrimidine-6-carboxamide
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 847559-80-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₁H₂₃Cl₂N₅O₂S
Molecular Weight: 480.4
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: EtOH (~5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent oral inhibitor of Hsp90β
MDL Number: N/A
PubChem CID: 25210273
SMILES: CCNC(=O)C1=CC2=C(N=C(N=C2S1)N)C3=CC(=C(C=C3Cl)Cl)OCCN4CCCC4
InChi: InChI=1S/C21H23Cl2N5O2S/c1-2-25-19(29)17-10-13-18(26-21(24)27-20(13)31-17)12-9-16(15(23)11-14(12)22)30-8-7-28-5-3-4-6-28/h9-11H,2-8H2,1H3,(H,25,29)(H2,24,26,27)
InChi Key: WJUNQSYQHHIVFX-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |