Description
A potent, selective small-molecule inhibitor of the receptor tyrosine kinase EphB4 (ED₅₀ = 25 nM). Displays selectivity for EphB4 over >40 other kinases in vitro, including FGFR3. NVP-BHG712 blocks Ephrin receptor autophosphorylation and VEGF-induced angiogenesis.
NVP-BHG712 is a potent, selective small-molecule inhibitor of the receptor tyrosine kinase EphB4 (ED₅₀ = 25 nM).
Alternate Name/Synonyms: 4-Methyl-3-[[1-methyl-6-(3-pyridiny l)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(t rifluoromethyl)phenyl]benzamide
Appearance: Off-white solid
Formulation: N/A
CAS Number: 940310-85-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₆H₂₀F₃N₇O
Molecular Weight: 503.48
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (> 100 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, inhibitor of the receptor tyrosine kinase EphB4
MDL Number: N/A
PubChem CID: 16747388
SMILES: CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=Canonical SMILES : CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=CC=C5
InChi: InChI=1S/C26H20F3N7O/c1-15-8-9-16(25(37)32-19-7-3-6-18(12-19)26(27,28)29)11-21(15)33-23-20-14-31-36(2)24(20)35-22(34-23)17-5-4-10-30-13-17/h3-14H,1-2H3,(H,32,37)(H,33,34,35)
InChi Key: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |