NVP-BHG712 | 2464

A potent, selective small-molecule inhibitor of the receptor tyrosine kinase EphB4 (ED₅₀ = 25 nM). Displays selectivity for EphB4 over >40 other kinases in vitro, including FGFR3. NVP-BHG712 blocks Ephrin receptor autophosphorylation and VEGF-induced angiogenesis.

NVP-BHG712 is a potent, selective small-molecule inhibitor of the receptor tyrosine kinase EphB4 (ED₅₀ = 25 nM).

2464 | NVP-BHG712 DataSheet

Alternate Name/Synonyms: 4-Methyl-3-[[1-methyl-6-(3-pyridiny l)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(t rifluoromethyl)phenyl]benzamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 940310-85-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₀F₃N₇O

Molecular Weight: 503.48

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (> 100 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, inhibitor of the receptor tyrosine kinase EphB4

MDL Number: N/A

PubChem CID: 16747388

SMILES: CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=Canonical SMILES : CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=CC=C5

InChi: InChI=1S/C26H20F3N7O/c1-15-8-9-16(25(37)32-19-7-3-6-18(12-19)26(27,28)29)11-21(15)33-23-20-14-31-36(2)24(20)35-22(34-23)17-5-4-10-30-13-17/h3-14H,1-2H3,(H,32,37)(H,33,34,35)

InChi Key: ZCCPLJOKGAACRT-UHFFFAOYSA-N