NVP-BSK805 dihydrochloride | B2200

NVP-BSK805 is a potent and selective ATP-competitive inhibitor of JAK2 (IC₅₀ = 0.5 nM,). It displays >20-fold selectivity towards JAK1, JAK3 and TYK2.

NVP-BSK805 is a potent and selective ATP-competitive inhibitor of JAK2 (IC₅₀ = 0.5 nM,). It displays >20-fold selectivity towards JAK1, JAK3 and TYK2.

B2200 | NVP-BSK805 dihydrochloride DataSheet

Alternate Name/Synonyms: 4-(2,6-difluoro-4-(3-(1-(pip4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine, dihydrochloride

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1942919-79-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₈F₂N₆O • 2HCl

Molecular Weight: 563.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective ATP-competitive JAK2 inhibitor

MDL Number: N/A

PubChem CID: 57339395

SMILES: C1CNCCC1N2C=C(C=N2)C3=NC4=C(C=CC=C4N=C3)C5=CC(=C(C(=C5)F)CN6CCOCC6)F.Cl.Cl

InChi: InChI=1S/C27H28F2N6O.2ClH/c28-23-12-18(13-24(29)22(23)17-34-8-10-36-11-9-34)21-2-1-3-25-27(21)33-26(15-31-25)19-14-32-35(16-19)20-4-6-30-7-5-20;;/h1-3,12-16,20,30H,4-11,17H2;2*1H

InChi Key: NUOCAPALWRHKCU-UHFFFAOYSA-N