Description
ONO-4059 is a highly selective, orally bioavailable BTK (Bruton’s Tyrosine Kinase) inhibitor with a potency an IC₅₀ of 2.2 nM.
ONO-4059 is a highly selective, orally bioavailable BTK (Bruton’s Tyrosine Kinase) inhibitor with a potency an IC₅₀ of 2.2 nM.
Alternate Name/Synonyms: (R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1351636-18-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₅H₂₂N₆O₃
Molecular Weight: 454.48
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A highly selective, orally bioavailable BTK (Bruton’s Tyrosine Kinase) inhibitor
MDL Number: N/A
PubChem CID: 54755438
SMILES: CC#CC(=O)N1CCC(C1)N2C3=C(C(=NC=N3)N)N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5
InChi: InChI=1S/C25H22N6O3/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28)/t18-/m1/s1
InChi Key: SEJLPXCPMNSRAM-GOSISDBHSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |