ONO-4059 | B1283

ONO-4059 is a highly selective, orally bioavailable BTK (Bruton’s Tyrosine Kinase) inhibitor with a potency an IC₅₀ of 2.2 nM.

ONO-4059 is a highly selective, orally bioavailable BTK (Bruton’s Tyrosine Kinase) inhibitor with a potency an IC₅₀ of 2.2 nM.

B1283 | ONO-4059 DataSheet

Alternate Name/Synonyms: (R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1351636-18-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₂N₆O₃

Molecular Weight: 454.48

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A highly selective, orally bioavailable BTK (Bruton’s Tyrosine Kinase) inhibitor

MDL Number: N/A

PubChem CID: 54755438

SMILES: CC#CC(=O)N1CCC(C1)N2C3=C(C(=NC=N3)N)N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5

InChi: InChI=1S/C25H22N6O3/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28)/t18-/m1/s1

InChi Key: SEJLPXCPMNSRAM-GOSISDBHSA-N