Description
OSI-420 is an active metabolite of Erlotinib (Cat. No. 1588) which is an orally active EGFR tyrosine kinase inhibitor with IC₅₀ of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells
OSI-420 is an active metabolite of Erlotinib (Cat. No. 1588) which is an orally active EGFR tyrosine kinase inhibitor with IC₅₀ of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells
Alternate Name/Synonyms: 2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol, hydrochloride; CP-473420
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 183320-51-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₁H₂₂ClN₃O₄
Molecular Weight: 415.87
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent EGFR tyrosine kinase inhibitor
MDL Number: N/A
PubChem CID: 18924996
SMILES: COCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO.Cl
InChi: InChI=1S/C21H21N3O4.ClH/c1-3-15-5-4-6-16(11-15)24-21-17-12-19(27-8-7-25)20(28-10-9-26-2)13-18(17)22-14-23-21;/h1,4-6,11-14,25H,7-10H2,2H3,(H,22,23,24);1H
InChi Key: BUOXOWNQZVIETJ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |