OSI-420 | B2201

OSI-420 is an active metabolite of Erlotinib (Cat. No. 1588) which is an orally active EGFR tyrosine kinase inhibitor with IC₅₀ of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells

OSI-420 is an active metabolite of Erlotinib (Cat. No. 1588) which is an orally active EGFR tyrosine kinase inhibitor with IC₅₀ of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells

B2201 | OSI-420 DataSheet

Alternate Name/Synonyms: 2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol, hydrochloride; CP-473420

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 183320-51-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₂ClN₃O₄

Molecular Weight: 415.87

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent EGFR tyrosine kinase inhibitor

MDL Number: N/A

PubChem CID: 18924996

SMILES: COCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO.Cl

InChi: InChI=1S/C21H21N3O4.ClH/c1-3-15-5-4-6-16(11-15)24-21-17-12-19(27-8-7-25)20(28-10-9-26-2)13-18(17)22-14-23-21;/h1,4-6,11-14,25H,7-10H2,2H3,(H,22,23,24);1H

InChi Key: BUOXOWNQZVIETJ-UHFFFAOYSA-N