Osilodrostat | B3108

Osilodrostat is a potent inhibitor of the enzymes 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2), which catalyze the final steps of cortisol and aldosterone biosynthesis, respectively, in the adrenal cortex. Osilodrostat inhibits 11β-hydroxylase and aldosterone synthase with IC₅₀ values of 2.5 nM and 0.7 nM respectively. It is used to lower cortisol levels in the treatment of Cushing's disease.

Osilodrostat is a potent inhibitor of the enzymes 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2), which catalyze the final steps of cortisol and aldosterone biosynthesis, respectively, in the adrenal cortex. Osilodrostat inhibits 11β-hydroxylase and aldosterone synthase with IC₅₀ values of 2.5 nM and 0.7 nM respectively. It is used to lower cortisol levels in the treatment of Cushing's disease.

B3108 | Osilodrostat DataSheet

Alternate Name/Synonyms: LCI699; 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile

Appearance: White powder

Formulation:

CAS Number: 928134-65-0

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₃H₁₀FN₃

Molecular Weight: 227.24

Cell-Permeable?: True

Purity: ≥ 98%

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent inhibitor of 11β-hydroxylase and aldosterone synthase

MDL Number: MFCD25976825

PubChem CID: 44139752

SMILES: C1CC2=CN=CN2C1C3=C(C=C(C=C3)C#N)F

InChi: InChI=1S/C13H10FN3/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13/h1,3,5,7-8,13H,2,4H2/t13-/m1/s1

InChi Key: USUZGMWDZDXMDG-CYBMUJFWSA-N