Otenabant Hydrochloride | B3117

Otenabant is a novel cannabinoid type 1 (CB1) receptor antagonist. It is effective at subnanomolar concentrations at human CB1 receptors in binding and functional assays, with Ki values of 0.7 nM and 0.12 nM respectively. It reverses cannabinoid agonist-induced responses, reduces food intake, and increases energy expenditure and oxidation of fat in rodent models.

Otenabant is a novel cannabinoid type 1 (CB1) receptor antagonist. It is effective at subnanomolar concentrations at human CB1 receptors in binding and functional assays, with Ki values of 0.7 nM and 0.12 nM respectively. It reverses cannabinoid agonist-induced responses, reduces food intake, and increases energy expenditure and oxidation of fat in rodent models.

B3117 | Otenabant Hydrochloride DataSheet

Alternate Name/Synonyms: CP-945598 HCl; CP-945,598; 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]-4-(ethylamino)piperidine-4-carboxamide;hydrochloride; 1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride

Appearance: White to off-white solid powder

Formulation:

CAS Number: 686347-12-6

Structure Available?: TRUE

Peptide sequence:

Salt Form: TRUE

Molecular Formula: C₂₅H₂₆Cl₃N₇O

Molecular Weight: 546.88

Cell-Permeable?: True

Purity: ≥ 98%

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A novel CB1 receptor antagonist

MDL Number: MFCD18251544

PubChem CID: 16223963

SMILES: CCNC1(CCN(CC1)C2=NC=NC3=C2N=C(N3C4=CC=C(C=C4)Cl)C5=CC=CC=C5Cl)C(=O)N.Cl

InChi: InChI=1S/C25H25Cl2N7O.ClH/c1-2-31-25(24(28)35)11-13-33(14-12-25)22-20-23(30-15-29-22)34(17-9-7-16(26)8-10-17)21(32-20)18-5-3-4-6-19(18)27;/h3-10,15,31H,2,11-14H2,1H3,(H2,28,35);1H

InChi Key: KPYUQCJBZGQHPL-UHFFFAOYSA-N