Description
A potent PI3K/Akt/mTOR inhibitor that inhibits the TORC1 and TORC2 complexes. Displays inhibition of both Akt signaling and mTOR signaling similarly in tumor and vasculature. P529 inhibits tumor growth, angiogenesis and vascular permeability.
P529 is a potent PI3K/Akt/mTOR inhibitor that inhibits the TORC1 and TORC2 complexes.
Alternate Name/Synonyms: 3-(4-methoxybenzyloxy)-8-(1-hydroxyethyl)-2-methoxy-6H-benzo[c]chromen-6-one ; Palomid 529
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 914913-88-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₂O₆
Molecular Weight: 406.43
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~ 40 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent PI3K/Akt/mTOR inhibitor
MDL Number: N/A
PubChem CID: 11998575
SMILES: CC(C1=CC2=C(C=C1)C3=CC(=C(C=C3OC2=O)OCC4=CC=C(C=C4)OC)OC)O
InChi: InChI=1S/C24H22O6/c1-14(25)16-6-9-18-19-11-22(28-3)23(12-21(19)30-24(26)20(18)10-16)29-13-15-4-7-17(27-2)8-5-15/h4-12,14,25H,13H2,1-3H3
InChi Key: YEAHTLOYHVWAKW-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |