PARP10 Antibody (Center) [APR33482G]

PARP10 Antibody (Center) [APR33482G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PARP10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 565-597 amino acids from the Central region of human PARP10.

Cellular Localisation: Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nuclear and cytoplasmic compartment (PubMed:15674325) . A subpopulation concentrates in the nucleolus during late G1/S phase (PubMed:15674325)

Molecular Weight: 109998

Clone: Polyclonal

Gene Name: PARP10 (HGNC:25895)

Gene ID: 84875

Function: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379) . In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833) . Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125) . Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737) .

Summary: Tissue Location: Highly expressed in spleen and thymus (PubMed:15674325) . Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes (PubMed:15674325) Low expression in heart, brain, placenta, lung, skeletal muscle, and colon (PubMed:15674325) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Poly [ADP-ribose] polymerase 10, PARP-10, 2.4.2.30, ADP-ribosyltransferase diphtheria toxin-like 10, ARTD10, PARP10