LBD
PARP10 Antibody (Center) [APR33482G]
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- LBD-APR33482G
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Description
PARP10 Antibody (Center) [APR33482G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This PARP10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 565-597 amino acids from the Central region of human PARP10.
Cellular Localisation: Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nuclear and cytoplasmic compartment (PubMed:15674325) . A subpopulation concentrates in the nucleolus during late G1/S phase (PubMed:15674325)
Molecular Weight: 109998
Clone: Polyclonal
Gene Name: PARP10 (HGNC:25895)
Gene ID: 84875
Function: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379) . In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833) . Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125) . Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737) .
Summary: Tissue Location: Highly expressed in spleen and thymus (PubMed:15674325) . Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes (PubMed:15674325) Low expression in heart, brain, placenta, lung, skeletal muscle, and colon (PubMed:15674325) .
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Poly [ADP-ribose] polymerase 10, PARP-10, 2.4.2.30, ADP-ribosyltransferase diphtheria toxin-like 10, ARTD10, PARP10