PD-146176 | B2313

A specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM). Displays only weak effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC₅₀ = 0.54 μM for 15-LOX in rabbit reticulocytes).

PD-146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM). Displays only weak effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC₅₀ = 0.54 μM for 15-LOX in rabbit reticulocytes).

B2313 | PD-146176 DataSheet

Alternate Name/Synonyms: NSC-168807,6,11-dihydro-[1]benzothiopyrano[4,3-b]indole

Appearance: White to off-white solid

Formulation:

CAS Number: 4079-26-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₅H₁₁NS

Molecular Weight: 237.32

Cell-Permeable?:

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A 15-lipoxygenase (15-LOX) inhibitor

MDL Number: MFCD05664738

PubChem CID: 297589

SMILES: C1C2=C(C3=CC=CC=C3S1)NC4=CC=CC=C24

InChi: InChI=1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2

InChi Key: ZGOOPZVQMLHPFM-UHFFFAOYSA-N