Description
A specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM). Displays only weak effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC₅₀ = 0.54 μM for 15-LOX in rabbit reticulocytes).
PD-146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM). Displays only weak effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC₅₀ = 0.54 μM for 15-LOX in rabbit reticulocytes).
Alternate Name/Synonyms: NSC-168807,6,11-dihydro-[1]benzothiopyrano[4,3-b]indole
Appearance: White to off-white solid
Formulation:
CAS Number: 4079-26-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₅H₁₁NS
Molecular Weight: 237.32
Cell-Permeable?:
Purity: ≥98% by HPLC
Solubilities: DMSO (>10 mg/ml)
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A 15-lipoxygenase (15-LOX) inhibitor
MDL Number: MFCD05664738
PubChem CID: 297589
SMILES: C1C2=C(C3=CC=CC=C3S1)NC4=CC=CC=C24
InChi: InChI=1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2
InChi Key: ZGOOPZVQMLHPFM-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |