Description
PDCL Antibody | 7871 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: Predicted species reactivity based on immunogen sequence: Bovine: (94%)
Immunogen: PDCL antibody was raised against a 16 amino acid peptide near the amino terminus of human PDCL.
The immunogen is located within the first 50 amino acids of PDCL.
Research Area: Signal Transduction
Tested Application: E, WB
Application: PDCL antibody can be used for detection of PDCL by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Specificiy: PDCL antibody is human, mouse and rat reactive. At least two isoforms of PDCL are known to exist. PDCL antibody is predicted to not cross-react with other members of the PDCL protein family.
Positive Control 1: Cat. No. 1204 - K562 Cell Lysate
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Predicted: 33 kDa
Observed: 35 kDa
Validation: N/A
Isoform: N/A
Purification: PDCL antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PDCL antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: PDCL antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Alternate Name: PDCL Antibody: PhLP, PHLOP1, PhLP1, Phosducin-like protein, PHLP
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling (1, 2) . PDCL is widely expressed in normal human tissues and may participate directly in the regulation of calcium-evoked exocytosis in adrenal medullary chromaffin cells (3) . It is an ethanol-responsive modulator of heterotrimeric G proteins (4) .