PDCL Antibody | 7871

PDCL Antibody | 7871 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Bovine: (94%)

Immunogen: PDCL antibody was raised against a 16 amino acid peptide near the amino terminus of human PDCL.
The immunogen is located within the first 50 amino acids of PDCL.

Research Area: Signal Transduction

Tested Application: E, WB

Application: PDCL antibody can be used for detection of PDCL by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Specificiy: PDCL antibody is human, mouse and rat reactive. At least two isoforms of PDCL are known to exist. PDCL antibody is predicted to not cross-react with other members of the PDCL protein family.

Positive Control 1: Cat. No. 1204 - K562 Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 33 kDa
Observed: 35 kDa

Validation: N/A

Isoform: N/A

Purification: PDCL antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PDCL antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: PDCL antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: PDCL Antibody: PhLP, PHLOP1, PhLP1, Phosducin-like protein, PHLP

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling (1, 2) . PDCL is widely expressed in normal human tissues and may participate directly in the regulation of calcium-evoked exocytosis in adrenal medullary chromaffin cells (3) . It is an ethanol-responsive modulator of heterotrimeric G proteins (4) .