PEN2 | gamma-secretase subunit PEN-2 | AS06 154

PEN2 | gamma-secretase subunit PEN-2 | AS06 154 | Gentaur UK, US & Europe Distribution

Immunogen: The antibody was raised against the N-terminal eleven residues of human PEN-2. PEN-2 is the smallest component of the multi-protein gamma-secretase complex. Chosen synthetic peptide has been conjugated to KLH

Host: Rabbit

Conjugation: N/A

Clonality: Polyclonal

Isotype: N/A

Purity: Immunogen affinity purified serum in PBS pH 7.4.

Format: Lyophilized

Tested Application: Western blot (WB)

Related Products: Alzheimer | available antibodies for Alzheimer's diseaseSecondary antibodies

Recommended Dilutions: 1 : 250 (WB)

Molecular weight: 15 kDa

Confirmed Reactivity: Human, Mouse, Hamster

Predicted Reactivity: Bovine, Xenopus laevis (Frog), Rat

Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Additional Information: Approx, MW of the target protein is 15 kDa, Antibodies recognize also an unknown protein at around 40 kDa

Background: One characteristic feature of Alzheimer's disease is the deposition of amyloid-beta peptide (Abeta) as amyloid plaques within specific regions of the human brain. Abeta is derived from the amyloid-beta peptide precursor protein (beta-APP) by the intramembranous cleavage activity of gamma-secretase. PEN-2 (Q9NZ42) is a critical component of PS1/gamma secretase (Farmery et al. 2003; Bergman et al. 2004) .Alternative name: presenilin enhancer protein 2

Reconstitution: For reconstitution add 83, 3 µl of sterile water

Storage: Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

TAIR Nnumbre: N/A

Category: Alzheimer's disease

Research Area: Pathology