451 Recombinant Proteins and Cell culture
PEN2 | gamma-secretase subunit PEN-2 | AS06 154
- SKU:
- 451-AS06 154
- Availability:
- Usually ships in 5 working days
Description
PEN2 | gamma-secretase subunit PEN-2 | AS06 154 | Gentaur UK, US & Europe Distribution
Immunogen: The antibody was raised against the N-terminal eleven residues of human PEN-2. PEN-2 is the smallest component of the multi-protein gamma-secretase complex. Chosen synthetic peptide has been conjugated to KLH
Host: Rabbit
Conjugation: N/A
Clonality: Polyclonal
Isotype: N/A
Purity: Immunogen affinity purified serum in PBS pH 7.4.
Format: Lyophilized
Tested Application: Western blot (WB)
Related Products: Alzheimer | available antibodies for Alzheimer's diseaseSecondary antibodies
Recommended Dilutions: 1 : 250 (WB)
Molecular weight: 15 kDa
Confirmed Reactivity: Human, Mouse, Hamster
Predicted Reactivity: Bovine, Xenopus laevis (Frog), Rat
Not reactive in: No confirmed exceptions from predicted reactivity are currently known
Additional Information: Approx, MW of the target protein is 15 kDa, Antibodies recognize also an unknown protein at around 40 kDa
Background: One characteristic feature of Alzheimer's disease is the deposition of amyloid-beta peptide (Abeta) as amyloid plaques within specific regions of the human brain. Abeta is derived from the amyloid-beta peptide precursor protein (beta-APP) by the intramembranous cleavage activity of gamma-secretase. PEN-2 (Q9NZ42) is a critical component of PS1/gamma secretase (Farmery et al. 2003; Bergman et al. 2004) .Alternative name: presenilin enhancer protein 2
Reconstitution: For reconstitution add 83, 3 µl of sterile water
Storage: Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
TAIR Nnumbre: N/A
Category: Alzheimer's disease
Research Area: Pathology