PEN2 polyclonal Antibody | BS91050

PEN2 polyclonal Antibody | BS91050 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC IHC FC

Application Range: WB:1:500-1:2,000 IHC:1:50-1:200 ICC:1:50-1:200 FC:1:50-1:100

Background: Four proteins comprise the gamma-secretase complex: presenilin, nicastrin, aph-1, and PEN-2. Together, these proteins mediate cell surface signaling pathways for a variety of type I membrane proteins, notably amyloid-beta precursor protein, a protein implicated in the development of Alzheimer's disease, via intramembrane proteolysis. The proteins assemble into a proteolytically active complex in the golgi/trans-golgi network (TGN) compartments. Assembly leads to autocleavage of presenilin into two subunits to create the active site of gamma-secretase, an important step in understanding the mechanisms involved in the etiology and possible treatment of Alzheimer's disease.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: PEN2 polyclonal Antibody detects endogenous levels of PEN2 protein.

Molecular Weight: 12 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PSENEN, PEN2, MDS033, Gamma secretase subunit PEN 2, Gamma Secretase Subunit PEN2, Gamma-secretase subunit PEN-2, Hematopoietic stem/progenitor cells protein MDS033, MDS033, MSTP064, PEN 2, PEN2, Presenilin Enhancer 2, Presenilin enhancer 2 homolog, Presenilin enhancer protein 2, PSEN2, psenen,

Immunogen: Synthetic peptide corresponding to C-terminal human PEN2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: