Description
PEN2 polyclonal Antibody | BS91050 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB ICC IHC FC
Application Range: WB:1:500-1:2,000 IHC:1:50-1:200 ICC:1:50-1:200 FC:1:50-1:100
Background: Four proteins comprise the gamma-secretase complex: presenilin, nicastrin, aph-1, and PEN-2. Together, these proteins mediate cell surface signaling pathways for a variety of type I membrane proteins, notably amyloid-beta precursor protein, a protein implicated in the development of Alzheimer's disease, via intramembrane proteolysis. The proteins assemble into a proteolytically active complex in the golgi/trans-golgi network (TGN) compartments. Assembly leads to autocleavage of presenilin into two subunits to create the active site of gamma-secretase, an important step in understanding the mechanisms involved in the etiology and possible treatment of Alzheimer's disease.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: PEN2 polyclonal Antibody detects endogenous levels of PEN2 protein.
Molecular Weight: 12 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: PSENEN, PEN2, MDS033, Gamma secretase subunit PEN 2, Gamma Secretase Subunit PEN2, Gamma-secretase subunit PEN-2, Hematopoietic stem/progenitor cells protein MDS033, MDS033, MSTP064, PEN 2, PEN2, Presenilin Enhancer 2, Presenilin enhancer 2 homolog, Presenilin enhancer protein 2, PSEN2, psenen,
Immunogen: Synthetic peptide corresponding to C-terminal human PEN2.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: