Description
Pentostatin is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Pentostatin is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Pentostatin is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Pentostatin is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Alternate Name/Synonyms: (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol; Deoxycoformycin
Appearance: White solid
Formulation: N/A
CAS Number: 53910-25-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₁H₁₆N₄O₄
Molecular Weight: 268.27
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>20 mg/ml) or H₂O (>20mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: An irreversible adenosine deaminase inhibitor
MDL Number: MFCD00078802
PubChem CID: 439693
SMILES: C1C(C(OC1N2C=NC3=C2NC=NCC3O)CO)O
InChi: InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1
InChi Key: FPVKHBSQESCIEP-JQCXWYLXSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |