Pentostatin | B2038

Pentostatin is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Pentostatin is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

Pentostatin is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Pentostatin is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

B2038 | Pentostatin DataSheet

Alternate Name/Synonyms: (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol; Deoxycoformycin

Appearance: White solid

Formulation: N/A

CAS Number: 53910-25-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₁₆N₄O₄

Molecular Weight: 268.27

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml) or H₂O (>20mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An irreversible adenosine deaminase inhibitor

MDL Number: MFCD00078802

PubChem CID: 439693

SMILES: C1C(C(OC1N2C=NC3=C2NC=NCC3O)CO)O

InChi: InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1

InChi Key: FPVKHBSQESCIEP-JQCXWYLXSA-N