PF-3716556 | B3313

PF-3716556 is a selective H+,K+-ATPase inhibitor (pIC50 = 6 in human recombinant ion-leaky assays). Highly selective for H+,K+-ATPase in vitro; inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.

PF-3716556 is a selective H+,K+-ATPase inhibitor (pIC50 = 6 in human recombinant ion-leaky assays). Highly selective for H+,K+-ATPase in vitro; inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.

B3313 | PF-3716556 DataSheet

Alternate Name/Synonyms: 8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-imidazo[1,2-a]pyridine-6-carboxamide

Appearance: Off-white solid

Formulation:

CAS Number: 928774-43-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₆N₄O₃

Molecular Weight: 394.47

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >35 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective H+,K+-ATPase inhibitor

MDL Number:

PubChem CID: 25134521

SMILES: CC1=C2C(CCOC2=CC=C1)NC3=CC(=CN4C3=NC(=C4)C)C(=O)N(C)CCO

InChi: InChI=1S/C22H26N4O3/c1-14-5-4-6-19-20(14)17(7-10-29-19)24-18-11-16(22(28)25(3)8-9-27)13-26-12-15(2)23-21(18)26/h4-6,11-13,17,24,27H,7-10H2,1-3H3/t17-/m1/s1

InChi Key: YBHKBMJREUZHOV-QGZVFWFLSA-N