Description
PF-3716556 is a selective H+,K+-ATPase inhibitor (pIC50 = 6 in human recombinant ion-leaky assays). Highly selective for H+,K+-ATPase in vitro; inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.
PF-3716556 is a selective H+,K+-ATPase inhibitor (pIC50 = 6 in human recombinant ion-leaky assays). Highly selective for H+,K+-ATPase in vitro; inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.
Alternate Name/Synonyms: 8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-imidazo[1,2-a]pyridine-6-carboxamide
Appearance: Off-white solid
Formulation:
CAS Number: 928774-43-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₂₆N₄O₃
Molecular Weight: 394.47
Cell-Permeable?: TRUE
Purity: ≥98% by HPLC
Solubilities: >35 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A selective H+,K+-ATPase inhibitor
MDL Number:
PubChem CID: 25134521
SMILES: CC1=C2C(CCOC2=CC=C1)NC3=CC(=CN4C3=NC(=C4)C)C(=O)N(C)CCO
InChi: InChI=1S/C22H26N4O3/c1-14-5-4-6-19-20(14)17(7-10-29-19)24-18-11-16(22(28)25(3)8-9-27)13-26-12-15(2)23-21(18)26/h4-6,11-13,17,24,27H,7-10H2,1-3H3/t17-/m1/s1
InChi Key: YBHKBMJREUZHOV-QGZVFWFLSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |