Description
PF-477736 is a potent, ATP-competitive inhibitor of Chk1 (checkpoint kinase 1) (Ki =0.49 nM). It displays 100-fold selectivity over Chk2. PF-477736 abrogates DNA damage-induced cell cycle arrest.
PF-477736 is a potent, ATP-competitive inhibitor of Chk1 (checkpoint kinase 1) (Ki =0.49 nM). It displays 100-fold selectivity over Chk2. PF-477736 abrogates DNA damage-induced cell cycle arrest.
Alternate Name/Synonyms: (R)-α-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexaneacetamide
Appearance: Yellow solid
Formulation:
CAS Number: 952021-60-2
Structure Available?: Yes
Peptide sequence:
Salt Form:
Molecular Formula: C₂₂H₂₅N₇O₂
Molecular Weight: 419.48
Cell-Permeable?: TRUE
Purity: ≥98% by HPLC
Solubilities: >30 mg/ml (DMSO)
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A checkpoint kinase 1 (CHk1) inhibitor
MDL Number: MFCD16038847
PubChem CID: 16750408
SMILES: CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)C(C5CCCCC5)N
InChi: InChI=1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15
InChi Key: YFNWWNRZJGMDBR-LJQANCHMSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |