PF-477736 | B2335

PF-477736 is a potent, ATP-competitive inhibitor of Chk1 (checkpoint kinase 1) (Ki =0.49 nM). It displays 100-fold selectivity over Chk2. PF-477736 abrogates DNA damage-induced cell cycle arrest.

PF-477736 is a potent, ATP-competitive inhibitor of Chk1 (checkpoint kinase 1) (Ki =0.49 nM). It displays 100-fold selectivity over Chk2. PF-477736 abrogates DNA damage-induced cell cycle arrest.

B2335 | PF-477736 DataSheet

Alternate Name/Synonyms: (R)-α-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexaneacetamide

Appearance: Yellow solid

Formulation:

CAS Number: 952021-60-2

Structure Available?: Yes

Peptide sequence:

Salt Form:

Molecular Formula: C₂₂H₂₅N₇O₂

Molecular Weight: 419.48

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml (DMSO)

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A checkpoint kinase 1 (CHk1) inhibitor

MDL Number: MFCD16038847

PubChem CID: 16750408

SMILES: CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)C(C5CCCCC5)N

InChi: InChI=1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15

InChi Key: YFNWWNRZJGMDBR-LJQANCHMSA-N