PI3K-α Inhibitor | B1869

PI3Kα inhibitor is a potent and selective inhibitor of PI3Kα with IC₅₀ values of 2, 16, 660, and 220 nM for the α, β, γ, and 2Cβ isoforms, respectively. It inhibits PKA, KDR, PKCα, and cyclin E/Cdk2 significantly less effectively (IC₅₀ = 91, 3.4, 466, and 28 µM, respectively). PI3Kα inhibitor inhibits A375 melanoma cell proliferation with an IC₅₀ value of 580 nM.

PI3Kα inhibitor is a potent and selective inhibitor of PI3Kα with IC₅₀ values of 2, 16, 660, and 220 nM for the α, β, γ, and 2Cβ isoforms, respectively. It inhibits PKA, KDR, PKCα, and cyclin E/Cdk2 significantly less effectively (IC₅₀ = 91, 3.4, 466, and 28 µM, respectively). PI3Kα inhibitor inhibits A375 melanoma cell proliferation with an IC₅₀ value of 580 nM.

B1869 | PI3K-α Inhibitor DataSheet

Alternate Name/Synonyms: 3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol

Appearance: White solid

Formulation: N/A

CAS Number: 371943-05-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₆H₁₅N₃O₂S

Molecular Weight: 313.4

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective PI3Kα inhibitor

MDL Number: N/A

PubChem CID: 9901372

SMILES: C1COCCN1C2=NC(=NC3=C2SC=C3)C4=CC(=CC=C4)O

InChi: InChI=1S/C16H15N3O2S/c20-12-3-1-2-11(10-12)15-17-13-4-9-22-14(13)16(18-15)19-5-7-21-8-6-19/h1-4,9-10,20H,5-8H2

InChi Key: XXLAEKOWCYJOKK-UHFFFAOYSA-N