Description
PI3Kα inhibitor is a potent and selective inhibitor of PI3Kα with IC₅₀ values of 2, 16, 660, and 220 nM for the α, β, γ, and 2Cβ isoforms, respectively. It inhibits PKA, KDR, PKCα, and cyclin E/Cdk2 significantly less effectively (IC₅₀ = 91, 3.4, 466, and 28 µM, respectively). PI3Kα inhibitor inhibits A375 melanoma cell proliferation with an IC₅₀ value of 580 nM.
PI3Kα inhibitor is a potent and selective inhibitor of PI3Kα with IC₅₀ values of 2, 16, 660, and 220 nM for the α, β, γ, and 2Cβ isoforms, respectively. It inhibits PKA, KDR, PKCα, and cyclin E/Cdk2 significantly less effectively (IC₅₀ = 91, 3.4, 466, and 28 µM, respectively). PI3Kα inhibitor inhibits A375 melanoma cell proliferation with an IC₅₀ value of 580 nM.
B1869 | PI3K-α Inhibitor DataSheet
Alternate Name/Synonyms: 3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol
Appearance: White solid
Formulation: N/A
CAS Number: 371943-05-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₆H₁₅N₃O₂S
Molecular Weight: 313.4
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>25 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective PI3Kα inhibitor
MDL Number: N/A
PubChem CID: 9901372
SMILES: C1COCCN1C2=NC(=NC3=C2SC=C3)C4=CC(=CC=C4)O
InChi: InChI=1S/C16H15N3O2S/c20-12-3-1-2-11(10-12)15-17-13-4-9-22-14(13)16(18-15)19-5-7-21-8-6-19/h1-4,9-10,20H,5-8H2
InChi Key: XXLAEKOWCYJOKK-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |