PIM2 Polyclonal Antibody | E-AB-10916

PIM2 Polyclonal Antibody | E-AB-10916 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: OTTHUMP00000025825, Pim 2 oncogene, Pim 2h, Pim-2h, PIM2, PIM2 Oncogene, PIM2, Pim2h, Proto Oncogene PIM2, Proto-oncogene Pim-2 (serine threonine kinase), Serine/threonine kinase PIM2, Serine/threonine-protein kinase Pim-2

Application: IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Signal Transduction

Background: This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival. Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity.

Concentration: 0.3 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant protein of human PIM2

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: IHC 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A