PRDM2 Antibody (RIZ1)| F40202-0.08ML

PRDM2 Antibody (RIZ1)| F40202-0.08ML | Gentaur UK, US & Europe Distribution

Background: This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.

Format: Purified

Clone: 33AT1045

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Isotype: Mouse IgG1

Species Reactivity: Human, Mouse

Predicted Spacies Reactivity: N/A

Application: CHIP, WB, ELISA

Application Details: Western blot: 1:1000, ChIP: 1:100

Application Note: Titration of the RIZ1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This RIZ1 antibody is available for research use only.

Purity: Purified

Immunogen: Purified recombinant GST fusion protein encoding aa 1-347 of human RIZ1. This RIZ1 antibody is specific and does not recognize the beta isoform (RIZ2).

Storage: Aliquot the RIZ1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A