GNAS Antibody (G protein alpha S)| F40026-0.08ML

GNAS Antibody (G protein alpha S)| F40026-0.08ML | Gentaur UK, US & Europe Distribution

Background: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Mouse, Rat, Bovine, Pig, Hamster

Application: WB, IHC, IF, FACS, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Flow Cytometry: 1:10-1:50

Application Note: Titration of the GNAS antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This GNAS antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 287-315 from the human protein was used as the immunogen for this GNAS antibody.

Storage: Aliquot the GNAS antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A